Picalm (BC011470) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR209799L4V

  • LentiORF®

Lenti ORF particles, Picalm (GFP-tagged) - Mouse phosphatidylinositol binding clathrin assembly protein (cDNA clone MGC:19382 IMAGE:2651109), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 11,115.00


货期*
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规格
    • 200 ul

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经常一起买 (2)
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Specifications

Product Data
Product Name Picalm (BC011470) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms MGC19382, CALM, CLTH, MGC36413, MGC36616, PAP180, mKIAA4114
Vector pLenti-C-mGFP-P2A-Puro
ACCN BC011470
ORF Size 1965 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR209799).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC011470.1
RefSeq Size 3371 bp
RefSeq ORF 1967 bp
Locus ID 233489
Gene Summary Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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