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Srpk2 (NM_009274) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210006L3V
- LentiORF®
-
Lenti ORF particles, Srpk2 (Myc-DDK-tagged) - Mouse serine/arginine-rich protein specific kinase 2 (Srpk2), 200ul, >10^7 TU/mL
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CNY 11,590.00
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Specifications
| Product Data | |
| Product Name | Srpk2 (NM_009274) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW226533; AW492537; AW547358; mSRPK2; Wbp6 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_009274 |
| ORF Size | 2049 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210006).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009274.2, NP_033300.2 |
| RefSeq Size | 6436 bp |
| RefSeq ORF | 2049 bp |
| Locus ID | 20817 |
| Gene Summary | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28.[UniProtKB/Swiss-Prot Function] |
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