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Dtx3l (NM_001013371) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210070L3V
- LentiORF®
-
Lenti ORF particles, Dtx3l (Myc-DDK-tagged) - Mouse deltex 3-like (Drosophila) (Dtx3l), 200ul, >10^7 TU/mL
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CNY 12,350.00
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Specifications
| Product Data | |
| Product Name | Dtx3l (NM_001013371) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AU042200; BC023741 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001013371 |
| ORF Size | 2076 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210070).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001013371.2 |
| RefSeq Size | 5181 bp |
| RefSeq ORF | 2247 bp |
| Locus ID | 209200 |
| Gene Summary | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes.[UniProtKB/Swiss-Prot Function] |
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