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Slc26a6 (NM_134420) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210360L3V
- LentiORF®
-
Lenti ORF particles, Slc26a6 (Myc-DDK-tagged) - Mouse solute carrier family 26, member 6 (Slc26a6), 200ul, >10^7 TU/mL
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CNY 12,160.00
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Specifications
| Product Data | |
| Product Name | Slc26a6 (NM_134420) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | B930010B04Rik; CFEX; Pat-1; Pat1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_134420 |
| ORF Size | 2208 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210360).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_134420.3 |
| RefSeq Size | 3329 bp |
| RefSeq ORF | 2208 bp |
| Locus ID | 171429 |
| Gene Summary | Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.[UniProtKB/Swiss-Prot Function] |
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