Ercc2 (BC034517) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR210391L3V

  • LentiORF®

Lenti ORF particles, Ercc2 (Myc-DDK-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 2 (cDNA clone MGC:27532, 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 11,875.00


货期*
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规格
    • 200 ul

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经常一起买 (2)
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Specifications

Product Data
Product Name Ercc2 (BC034517) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms AA407812; AU020867; AW240756; CXPD; Ercc-2; Mhdarco15; RCO015; XPD
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN BC034517
ORF Size 2217 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR210391).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC034517, AAH34517
RefSeq Size 3500 bp
RefSeq ORF 2219 bp
Locus ID 13871
Gene Summary ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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