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Epha4 (BC004782) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211210L3V
- LentiORF®
-
Lenti ORF particles, Epha4 (Myc-DDK-tagged) - Mouse Eph receptor A4 (cDNA clone MGC:8084 IMAGE:3588285), 200ul, >10^7 TU/mL
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CNY 11,875.00
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Specifications
| Product Data | |
| Product Name | Epha4 (BC004782) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Sek1, Cek8, Hek8, Tyro1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC004782 |
| ORF Size | 2781 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211210).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC004782.1 |
| RefSeq Size | 3544 bp |
| RefSeq ORF | 2783 bp |
| Locus ID | 13838 |
| Gene Summary | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.[UniProtKB/Swiss-Prot Function] |
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