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Arhgef2 (NM_008487) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211388L3V
- LentiORF®
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Lenti ORF particles, Arhgef2 (Myc-DDK-tagged) - Mouse rho/rac guanine nucleotide exchange factor (GEF) 2 (Arhgef2), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 15,010.00
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Specifications
| Product Data | |
| Product Name | Arhgef2 (NM_008487) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AA408978; GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40; mKIAA0651; P40 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008487 |
| ORF Size | 2958 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211388).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008487.2, NP_032513.2 |
| RefSeq Size | 4300 bp |
| RefSeq ORF | 2958 bp |
| Locus ID | 16800 |
| Gene Summary | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519).[UniProtKB/Swiss-Prot Function] |
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