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Jak3 (NM_010589) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211635L4V
- LentiORF®
-
Lenti ORF particles, Jak3 (GFP-tagged) - Mouse Janus kinase 3 (Jak3), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 18,145.00
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Specifications
| Product Data | |
| Product Name | Jak3 (NM_010589) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | fae; wil |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010589 |
| ORF Size | 3303 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211635).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010589.3, NP_034719.2 |
| RefSeq Size | 3950 bp |
| RefSeq ORF | 3303 bp |
| Locus ID | 16453 |
| Gene Summary | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.[UniProtKB/Swiss-Prot Function] |
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