Npc1 (NM_008720) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR211885L3V
- LentiORF®
Lenti ORF particles, Npc1 (Myc-DDK-tagged) - Mouse Niemann Pick type C1 (Npc1), 200ul, >10^7 TU/mL
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CNY 18,335.00
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Specifications
Product Data | |
Product Name | Npc1 (NM_008720) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | A430089E03Rik; C85354; D18Ertd139e; D18Ertd723e; lcsd; nmf164; spm |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_008720 |
ORF Size | 3831 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR211885).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_008720.2, NP_032746.2 |
RefSeq Size | 5209 bp |
RefSeq ORF | 3834 bp |
Locus ID | 18145 |
Gene Summary | Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).[UniProtKB/Swiss-Prot Function] |
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