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Ncoa1 (NM_010881) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211972L4V
- LentiORF®
-
Lenti ORF particles, Ncoa1 (GFP-tagged) - Mouse nuclear receptor coactivator 1 (Ncoa1), 200ul, >10^7 TU/mL
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CNY 22,040.00
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规格
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Specifications
| Product Data | |
| Product Name | Ncoa1 (NM_010881) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1; SRC-1; SRC-a; SRC1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010881 |
| ORF Size | 4218 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211972).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010881.1 |
| RefSeq Size | 7346 bp |
| RefSeq ORF | 4218 bp |
| Locus ID | 17977 |
| Gene Summary | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.[UniProtKB/Swiss-Prot Function] |
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