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Vps41 (NM_172120) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218234L4V
- LentiORF®
-
Lenti ORF particles, Vps41 (GFP-tagged) - Mouse vacuolar protein sorting 41 (yeast) (Vps41), 200ul, >10^7 TU/mL
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CNY 15,010.00
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Specifications
| Product Data | |
| Product Name | Vps41 (NM_172120) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI317346; mVam2; Vam2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_172120 |
| ORF Size | 2559 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218234).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_172120.4, NP_742118.3 |
| RefSeq Size | 3212 bp |
| RefSeq ORF | 2562 bp |
| Locus ID | 218035 |
| Gene Summary | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex. May play a role in HOPS-independent function in the regulated secretory pathway (By similarity).[UniProtKB/Swiss-Prot Function] |
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