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Ran (NM_009391) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR219470L4V
- LentiORF®
-
Lenti ORF particles, Ran (GFP-tagged) - Mouse RAN, member RAS oncogene family (Ran), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Ran (NM_009391) Mouse Tagged ORF Clone Lentiviral Particle |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_009391 |
| ORF Size | 648 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR219470).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009391.3, NP_033417.1 |
| RefSeq Size | 2288 bp |
| RefSeq ORF | 651 bp |
| Locus ID | 19384 |
| Gene Summary | GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.[UniProtKB/Swiss-Prot Function] |
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