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Acvr1b (NM_007395) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR220419L3V
- LentiORF®
-
Lenti ORF particles, Acvr1b (Myc-DDK-tagged) - Mouse activin A receptor, type 1B (Acvr1b), 200ul, >10^7 TU/mL
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CNY 9,595.00
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Specifications
| Product Data | |
| Product Name | Acvr1b (NM_007395) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 6820432J04; ActR-IB; ActRIB; Acvrlk4; Alk4; SKR2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_007395 |
| ORF Size | 1518 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR220419).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_007395.3 |
| RefSeq Size | 3277 bp |
| RefSeq ORF | 1518 bp |
| Locus ID | 11479 |
| Gene Summary | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.[UniProtKB/Swiss-Prot Function] |
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