Plk2 (NM_152804) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR220913L3V
- LentiORF®
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Lenti ORF particles, Plk2 (Myc-DDK-tagged) - Mouse polo-like kinase 2 (Drosophila) (Plk2), 200ul, >10^7 TU/mL
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CNY 11,590.00
货期*
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规格
Cited in 1 publication. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | Plk2 (NM_152804) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Snk |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_152804 |
ORF Size | 2049 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR220913).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_152804.2 |
RefSeq Size | 2802 bp |
RefSeq ORF | 2049 bp |
Locus ID | 20620 |
Gene Summary | Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.[UniProtKB/Swiss-Prot Function] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies
,null,
The Journal of Neuroscience
,PubMed ID 28522732
[Plk2]
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