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Rarres2 (NM_027852) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222586L3V
- LentiORF®
-
Lenti ORF particles, Rarres2 (Myc-DDK-tagged) - Mouse retinoic acid receptor responder (tazarotene induced) 2 (Rarres2), 200ul, >10^7 TU/mL
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CNY 7,410.00
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规格
| Cited in 1 publication. |
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Specifications
| Product Data | |
| Product Name | Rarres2 (NM_027852) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 0610007L05Rik; AI303516 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_027852 |
| ORF Size | 486 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222586).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_027852.2, NP_082128.1 |
| RefSeq Size | 708 bp |
| RefSeq ORF | 489 bp |
| Locus ID | 71660 |
| Gene Summary | Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Serum RARRES2 Is a Prognostic Marker in Patients With Adrenocortical Carcinoma
,null,
The Journal of Clinical Endocrinology and Metabolism
,PubMed ID 27336360
[Rarres2]
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