Abcb4 (NM_008830) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR223301L4V

  • LentiORF®

Lenti ORF particles, Abcb4 (GFP-tagged) - Mouse ATP-binding cassette, sub-family B (MDR/TAP), member 4 (Abcb4), 200ul, >10^7 TU/mL.

ORF Plasmid: DDK tGFP



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CNY 20,330.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Abcb4 (NM_008830) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms mdr-2; Mdr2; Pgy-2; Pgy2
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_008830
ORF Size 3828 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR223301).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_008830.2
RefSeq Size 4083 bp
RefSeq ORF 3831 bp
Locus ID 18670
Gene Summary Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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