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Abcb4 (NM_008830) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR223301L4V
- LentiORF®
-
Lenti ORF particles, Abcb4 (GFP-tagged) - Mouse ATP-binding cassette, sub-family B (MDR/TAP), member 4 (Abcb4), 200ul, >10^7 TU/mL.
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CNY 20,330.00
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Specifications
| Product Data | |
| Product Name | Abcb4 (NM_008830) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | mdr-2; Mdr2; Pgy-2; Pgy2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_008830 |
| ORF Size | 3828 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR223301).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008830.2 |
| RefSeq Size | 4083 bp |
| RefSeq ORF | 3831 bp |
| Locus ID | 18670 |
| Gene Summary | Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275).[UniProtKB/Swiss-Prot Function] |
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