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Fbxw8 (NM_172721) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR223717L3V
- LentiORF®
-
Lenti ORF particles, Fbxw8 (Myc-DDK-tagged) - Mouse F-box and WD-40 domain protein 8 (Fbxw8), 200ul, >10^7 TU/mL
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CNY 10,640.00
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规格
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Specifications
| Product Data | |
| Product Name | Fbxw8 (NM_172721) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4930438M06Rik; FBW6; FBW8; Fbx29; FBXO29 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_172721 |
| ORF Size | 1797 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR223717).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_172721.2, NP_766309.2 |
| RefSeq Size | 4978 bp |
| RefSeq ORF | 1797 bp |
| Locus ID | 231672 |
| Gene Summary | Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).[UniProtKB/Swiss-Prot Function] |
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