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Brd7 (NM_012047) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR224080L3V
- LentiORF®
-
Lenti ORF particles, Brd7 (Myc-DDK-tagged) - Mouse bromodomain containing 7 (Brd7), 200ul, >10^7 TU/mL
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CNY 11,210.00
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规格
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Specifications
| Product Data | |
| Product Name | Brd7 (NM_012047) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | BP75; CELTIX1; Ptpn13ip |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_012047 |
| ORF Size | 1953 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR224080).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_012047.2 |
| RefSeq Size | 2370 bp |
| RefSeq ORF | 1956 bp |
| Locus ID | 26992 |
| Gene Summary | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.[UniProtKB/Swiss-Prot Function] |
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