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Nlrc3 (NM_001081280) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR224926L4V
- LentiORF®
-
Lenti ORF particles, Nlrc3 (GFP-tagged) - Mouse NLR family, CARD domain containing 3 (Nlrc3), 200ul, >10^7 TU/mL
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CNY 18,145.00
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Specifications
| Product Data | |
| Product Name | Nlrc3 (NM_001081280) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | CLR16.2; D230007K08Rik; mFLJ00348 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001081280 |
| ORF Size | 3306 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR224926).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001081280.1 |
| RefSeq Size | 4080 bp |
| RefSeq ORF | 3309 bp |
| Locus ID | 268857 |
| Gene Summary | Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (PubMed:22863753, PubMed:24560620). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (PubMed:27951586). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (By similarity). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (By similarity).[UniProtKB/Swiss-Prot Function] |
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