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Rfx3 (NM_001166414) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225016L3V
- LentiORF®
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Lenti ORF particles, Rfx3 (Myc-DDK-tagged) - Mouse regulatory factor X, 3 (influences HLA class II expression) (Rfx3), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 12,350.00
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Specifications
| Product Data | |
| Product Name | Rfx3 (NM_001166414) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | C230093O12Rik; MRFX3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001166414 |
| ORF Size | 2250 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225016).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001166414.1 |
| RefSeq Size | 9146 bp |
| RefSeq ORF | 2250 bp |
| Locus ID | 19726 |
| Gene Summary | Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells (PubMed:15121860, PubMed:19671664). Also required for ciliated ependymal cell differentiation (PubMed:16930429). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells (PubMed:17229940). Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (By similarity). Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.[UniProtKB/Swiss-Prot Function] |
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