United States
Germany
Japan
United Kingdom
China
Uhrf1 (NM_001111080) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226257L3V
- LentiORF®
-
Lenti ORF particles, Uhrf1 (Myc-DDK-tagged) - Mouse ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1), transcript variant 4, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 12,635.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Uhrf1 (NM_001111080) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AL022808; ICBP90; Np95; RNF106 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001111080 |
| ORF Size | 2322 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226257).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001111080.1, NP_001104550.1 |
| RefSeq Size | 3415 bp |
| RefSeq ORF | 2325 bp |
| Locus ID | 18140 |
| Gene Summary | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
