Smad7 (NM_001042660) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR226590L2V
- LentiORF®
Lenti ORF particles, Smad7 (GFP-tagged) - Mouse MAD homolog 7 (Drosophila) (Smad7), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
Product Data | |
Product Name | Smad7 (NM_001042660) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Madh7 |
Vector | pLenti-C-mGFP |
ACCN | NM_001042660 |
ORF Size | 1281 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR226590).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001042660.1, NP_001036125.1 |
RefSeq Size | 4441 bp |
RefSeq ORF | 1281 bp |
Locus ID | 17131 |
Gene Summary | Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.[UniProtKB/Swiss-Prot Function] |
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