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Kcnc3 (NM_008422) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226697L3V
- LentiORF®
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Lenti ORF particles, Kcnc3 (Myc-DDK-tagged) - Mouse potassium voltage gated channel, Shaw-related subfamily, member 3 (Kcnc3), 200ul, >10^7 TU/mL
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CNY 12,540.00
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Specifications
| Product Data | |
| Product Name | Kcnc3 (NM_008422) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Kcr2-3; KShIIID; Kv3.3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008422 |
| ORF Size | 2307 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226697).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008422.2, NP_032448.2 |
| RefSeq Size | 5072 bp |
| RefSeq ORF | 2310 bp |
| Locus ID | 16504 |
| Gene Summary | Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:18539595, PubMed:26997484, PubMed:24218544). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells (PubMed:15217387, PubMed:18448641, PubMed:24218544). Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (PubMed:24218544). Required for normal motor function (PubMed:16923152, PubMed:18448641). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).[UniProtKB/Swiss-Prot Function] |
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