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APH1A (NM_016022) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC203645L2V
- LentiORF®
-
Lenti ORF particles, APH1A (mGFP-tagged) - Human anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,360.00
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规格
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Specifications
| Product Data | |
| Product Name | APH1A (NM_016022) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | 6530402N02Rik; APH-1; APH-1A; CGI-78 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_016022 |
| ORF Size | 741 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC203645).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_016022.2 |
| RefSeq Size | 2290 bp |
| RefSeq ORF | 744 bp |
| Locus ID | 51107 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Alzheimer's disease, Notch signaling pathway |
| MW | 26.8 kDa |
| Gene Summary | This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011] |
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