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GTF2H2 (NM_001515) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC209543L4V
- LentiORF®
-
Lenti ORF particles, GTF2H2 (mGFP-tagged) - Human general transcription factor IIH, polypeptide 2, 44kDa (GTF2H2), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | GTF2H2 (NM_001515) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | BTF2; BTF2 p44; BTF2P44; p44; T-BTF2P44; TFIIH |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001515 |
| ORF Size | 1185 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC209543).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001515.3, NP_001506.1 |
| RefSeq Size | 1951 bp |
| RefSeq ORF | 1188 bp |
| Locus ID | 2966 |
| Domains | VWA, Ssl1 |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Basal transcription factors, Nucleotide excision repair |
| MW | 44.2 kDa |
| Gene Summary | This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008] |
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