United States
Germany
Japan
United Kingdom
China
Cezanne (OTUD7B) (NM_020205) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC209932L1V
- LentiORF®
-
Lenti ORF particles, OTUD7B (Myc-DDK tagged) - Human OTU domain containing 7B (OTUD7B), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Product Name | Cezanne (OTUD7B) (NM_020205) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CEZANNE; ZA20D1 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_020205 |
| ORF Size | 2529 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC209932).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_020205.2 |
| RefSeq Size | 6415 bp |
| RefSeq ORF | 2532 bp |
| Locus ID | 56957 |
| MW | 92.5 kDa |
| Gene Summary | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
其它Cezanne产品
