PPM1F (NM_014634) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC210043L4V
- LentiORF®
Lenti ORF particles, PPM1F (mGFP-tagged) - Human protein phosphatase, Mg2+/Mn2+ dependent, 1F (PPM1F), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
Product Data | |
Product Name | PPM1F (NM_014634) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_014634 |
ORF Size | 3534 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC210043).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_014634.2 |
RefSeq Size | 5199 bp |
RefSeq ORF | 1365 bp |
Locus ID | 9647 |
Domains | PP2C |
Protein Families | Druggable Genome, Phosphatase |
MW | 49.7 kDa |
Gene Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
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