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KSR2 (NM_173598) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC211665L3V
- LentiORF®
-
Lenti ORF particles, KSR2 (Myc-DDK tagged) - Human kinase suppressor of ras 2 (KSR2), 200ul, >10^7 TU/mL
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CNY 16,435.00
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Specifications
| Product Data | |
| Product Name | KSR2 (NM_173598) Human Tagged ORF Clone Lentiviral Particle |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_173598 |
| ORF Size | 2763 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC211665).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_173598.4, NP_775869.3 |
| RefSeq Size | 17008 bp |
| RefSeq ORF | 2853 bp |
| Locus ID | 283455 |
| Protein Families | Druggable Genome, Protein Kinase |
| MW | 104.1 kDa |
| Gene Summary | Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.[UniProtKB/Swiss-Prot Function] |
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