Myosin light chain kinase (MYLK) (NM_053025) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC215976L1V
- LentiORF®
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Lenti ORF particles, MYLK (Myc-DDK tagged) - Human myosin light chain kinase (MYLK), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 21,660.00
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Specifications
Product Data | |
Product Name | Myosin light chain kinase (MYLK) (NM_053025) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MMIHS; MMIHS1; MSTP083; MYLK1; smMLCK |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_053025 |
ORF Size | 5742 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC215976).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_053025.3 |
RefSeq Size | 7852 bp |
RefSeq ORF | 5745 bp |
Locus ID | 4638 |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Calcium signaling pathway, Focal adhesion, Regulation of actin cytoskeleton, Vascular smooth muscle contraction |
MW | 210.7 kDa |
Gene Summary | This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] |
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