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LRRK2 (NM_198578) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC216373L1V
- LentiORF®
-
Lenti ORF particles, LRRK2 (Myc-DDK tagged) - Human leucine-rich repeat kinase 2 (LRRK2), 200ul, >10^7 TU/mL
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CNY 21,660.00
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规格
| Cited in 2 publications. |
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经常一起买 (3)
热销推荐Specifications
| Product Data | |
| Product Name | LRRK2 (NM_198578) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | AURA17; DARDARIN; PARK8; RIPK7; ROCO2 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_198578 |
| ORF Size | 7581 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC216373).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_198578.2 |
| RefSeq Size | 9234 bp |
| RefSeq ORF | 7584 bp |
| Locus ID | 120892 |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Parkinson's disease |
| MW | 286.1 kDa |
| Gene Summary | This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.
,null,
Journal of neuroscience research
,PubMed ID 24375786
[LRRK2]
|
|
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
,null,
Nature
,PubMed ID 20671708
[LRRK2]
|
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