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NEDL2 (HECW2) (NM_020760) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC216544L3V
- LentiORF®
-
Lenti ORF particles, HECW2 (Myc-DDK tagged) - Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2), 200ul, >10^7 TU/mL
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CNY 11,210.00
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规格
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Specifications
| Product Data | |
| Product Name | NEDL2 (HECW2) (NM_020760) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | NDHSAL; NEDL2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_020760 |
| ORF Size | 4716 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC216544).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_020760.1 |
| RefSeq Size | 6926 bp |
| RefSeq ORF | 4719 bp |
| Locus ID | 57520 |
| Protein Families | Druggable Genome |
| MW | 175.6 kDa |
| Gene Summary | This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
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