UBE3A (NM_000462) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC216727L1V
- LentiORF®
-
Lenti ORF particles, UBE3A (Myc-DDK tagged) - Human ubiquitin protein ligase E3A (UBE3A), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 15,770.00
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Specifications
Product Data | |
Product Name | UBE3A (NM_000462) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | ANCR; AS; E6-AP; EPVE6AP; HPVE6A |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_000462 |
ORF Size | 2625 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC216727).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000462.2 |
RefSeq Size | 4516 bp |
RefSeq ORF | 2628 bp |
Locus ID | 7337 |
Domains | HECT |
Protein Families | Druggable Genome |
Protein Pathways | Ubiquitin mediated proteolysis |
MW | 100.5 kDa |
Gene Summary | This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
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