NUMBL (NM_004756) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC216869L4V
- LentiORF®
Lenti ORF particles, NUMBL (mGFP-tagged) - Human numb homolog (Drosophila)-like (NUMBL), 200ul, >10^7 TU/mL
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CNY 12,065.00
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Specifications
Product Data | |
Product Name | NUMBL (NM_004756) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_004756 |
ORF Size | 1827 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC216869).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_004756.4 |
RefSeq Size | 3568 bp |
RefSeq ORF | 1830 bp |
Locus ID | 9253 |
Domains | PID |
Protein Pathways | Notch signaling pathway |
MW | 64.9 kDa |
Gene Summary | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.[UniProtKB/Swiss-Prot Function] |
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