Transglutaminase 2 (TGM2) (NM_004613) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC217353L1V
- LentiORF®
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Lenti ORF particles, TGM2 (Myc-DDK tagged) - Human transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM2), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 13,205.00
Cited in 1 publication. |
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CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | Transglutaminase 2 (TGM2) (NM_004613) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | G(h); hTG2; TG(C); TGC; tTG |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_004613 |
ORF Size | 2061 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC217353).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_004613.2 |
RefSeq Size | 3937 bp |
RefSeq ORF | 2064 bp |
Locus ID | 7052 |
Domains | Transglutamin_C, TGc |
Protein Families | Druggable Genome |
Protein Pathways | Huntington's disease |
MW | 77.1 kDa |
Gene Summary | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN
,null,
BMC Cancer
,PubMed ID 22759359
[TGM2]
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