FBXW7 (NM_033632) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC217398L1V
- LentiORF®
Lenti ORF particles, FBXW7 (Myc-DDK tagged) - Human F-box and WD repeat domain containing 7 (FBXW7), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
Product Data | |
Product Name | FBXW7 (NM_033632) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; hAgo; hCdc4; SEL-10; SEL10 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_033632 |
ORF Size | 2121 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC217398).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_033632.2 |
RefSeq Size | 3896 bp |
RefSeq ORF | 2124 bp |
Locus ID | 55294 |
Domains | WD40, F-box |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Ubiquitin mediated proteolysis |
MW | 79.5 kDa |
Gene Summary | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] |
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