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ZNRF3 (NM_032173) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC219546L1V
- LentiORF®
-
Lenti ORF particles, ZNRF3 (Myc-DDK tagged) - Human zinc and ring finger 3 (ZNRF3), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 15,295.00
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| Product Data | |
| Product Name | ZNRF3 (NM_032173) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | BK747E2.3; RNF203 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_032173 |
| ORF Size | 2508 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC219546).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_032173.2, NP_115549.2 |
| RefSeq Size | 6541 bp |
| RefSeq ORF | 2511 bp |
| Locus ID | 84133 |
| Protein Families | Druggable Genome, Transmembrane |
| MW | 89.7 kDa |
| Gene Summary | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).[UniProtKB/Swiss-Prot Function] |
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