United States
Germany
Japan
United Kingdom
China
PLEKHM2 (NM_015164) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC220299L3V
- LentiORF®
-
Lenti ORF particles, PLEKHM2 (Myc-DDK tagged) - Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 17,765.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | PLEKHM2 (NM_015164) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | SKIP |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_015164 |
| ORF Size | 3057 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC220299).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_015164.1 |
| RefSeq Size | 4231 bp |
| RefSeq ORF | 3060 bp |
| Locus ID | 23207 |
| Protein Families | Druggable Genome |
| MW | 112.6 kDa |
| Gene Summary | This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
其它PLEKHM2产品
Customer
Reviews
Loading...
