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OTOP1 (NM_177998) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC221713L3V
- LentiORF®
-
Lenti ORF particles, OTOP1 (Myc-DDK-tagged)-Human otopetrin 1 (OTOP1), 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | OTOP1 (NM_177998) Human Tagged ORF Clone Lentiviral Particle |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_177998 |
| ORF Size | 1836 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC221713).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_177998.1, NP_819056.1 |
| RefSeq Size | 1869 bp |
| RefSeq ORF | 1839 bp |
| Locus ID | 133060 |
| Protein Families | Transmembrane |
| MW | 67.4 kDa |
| Gene Summary | This gene encodes a transmembrane protein which belongs to the otopetrin domain protein family and is required for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals that are required for the detection of linear acceleration and gravity. This gene modulates purinergic control of intracellular calcium in vestibular supporting cells. Naturally occurring mutations in the orthologous mouse gene are associated with nonsyndromic otoconia agenesis and a consequent balance defect. The orthologous mouse gene is also induced in white adipose tissue during obesity. The encoded protein is a component of a counterinflammatory pathway that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. [provided by RefSeq, Jul 2017] |
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