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SIGIRR (NM_001135053) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC225642L4V
- LentiORF®
-
Lenti ORF particles, SIGIRR (mGFP-tagged) - Human single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | SIGIRR (NM_001135053) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | IL-1R8; TIR8 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001135053 |
| ORF Size | 1230 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC225642).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001135053.1, NP_001128525.1 |
| RefSeq Size | 1688 bp |
| RefSeq ORF | 1233 bp |
| Locus ID | 59307 |
| Protein Families | Transcription Factors, Transmembrane |
| MW | 45.7 kDa |
| Gene Summary | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.[UniProtKB/Swiss-Prot Function] |
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