Neurofibromin (NF1) (NM_001128147) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC226001L3V
- LentiORF®
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Lenti ORF particles, NF1 (Myc-DDK tagged) - Human neurofibromin 1 (NF1), transcript variant 3, 200ul, >10^7 TU/mL
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CNY 10,545.00
货期*
详询
规格
Cited in 1 publication. |
经常一起买 (3)
Specifications
Product Data | |
Product Name | Neurofibromin (NF1) (NM_001128147) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | NFNS; VRNF; WSS |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001128147 |
ORF Size | 1779 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC226001).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001128147.1 |
RefSeq ORF | 1782 bp |
Locus ID | 4763 |
Protein Families | Druggable Genome |
Protein Pathways | MAPK signaling pathway |
MW | 67.4 kDa |
Gene Summary | This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers.
,null,
Cancer cell
,PubMed ID 31978326
[NF1]
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