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Usp10 (NM_001034146) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR201548L4V
- LentiORF®
-
Lenti ORF particles, Usp10 (GFP-tagged ORF) - Rat ubiquitin specific peptidase 10 (Usp10), 200ul, >10^7 TU/mL
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CNY 14,345.00
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Specifications
| Product Data | |
| Product Name | Usp10 (NM_001034146) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | MGC124997 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001034146 |
| ORF Size | 2382 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR201548).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001034146.1, NP_001029318.1 |
| RefSeq Size | 3287 bp |
| RefSeq ORF | 2385 bp |
| Locus ID | 307905 |
| Gene Summary | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization.[UniProtKB/Swiss-Prot Function] |
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