p27 KIP 1 (CDKN1B) (NM_004064) Human Mutant ORF Clone

CAT#: RC402693

  • TrueORF®

CDKN1B Mutant (I119T), Myc-DDK-tagged ORF clone of Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) as transfection-ready DNA



Need custom modification / cloning service?
Get a free quote

CNY 2,400.00

CNY 3,990.00


货期*
现货

规格
    • 10 ug

Product images

Specifications

Product Data
Product Name p27 KIP 1 (CDKN1B) (NM_004064) Human Mutant ORF Clone
Mutation Description I119T
Affected Codon# 119
Affected NT# 356
Nucleotide Mutation CDKN1B Mutant (I119T), Myc-DDK-tagged ORF clone of Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) as transfection-ready DNA
Effect Myeloproliferative syndrome
Synonyms CDKN4; KIP1; MEN1B; MEN4; P27KIP1
Vector pCMV6-Entry
Tag Myc-DDK
ACCN NM_004064
ORF Size 594 bp
Restriction Sites SgfI-MluI      Cloning Scheme for this gene     
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NP_004055
RefSeq Size 594 bp
RefSeq ORF 597 bp
Locus ID 1027
Domains CDI
Protein Families Druggable Genome
Protein Pathways Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer
MW 21.8 kDa
Gene Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...