PIK3C2G (NM_004570) Human Mutant ORF Clone

Specifications

Product Data
Product Name	PIK3C2G (NM_004570) Human Mutant ORF Clone
Mutation Description	P146L
Affected Codon#	146
Affected NT#	437
Nucleotide Mutation	PIK3C2G Mutant (P146L), Myc-DDK-tagged ORF clone of Homo sapiens phosphoinositide-3-kinase, class 2, gamma polypeptide (PIK3C2G) as transfection-ready DNA
Effect	Dibees, ype 2, ssoiion wih
Synonyms	PI3K-C2-gamma; PI3K-C2GAMMA
Vector	pCMV6-Entry
Tag	Myc-DDK
ACCN	NM_004570
ORF Size	4335 bp
Sequence Data	ORF Nucleotide Sequence (showhide) >RC402758 representing NM_004570 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCATATTCTTGGCAAACGGATCCAAATCCTAATGAATCACACGAAAAGCAGTATGAACACCAAGAAT TTCTCTTTGTAAATCAACCCCATTCTTCTAGCCAAGTCAGTCTGGGTTTTGATCAGATAGTAGATGAGAT CAGTGGCAAAATTCCACACTACGAGAGTGAAATTGATGAAAACACCTTTTTTGTGCCCACTGCACCAAAA TGGGACTCAACAGGGCATTCATTAAATGAAGCACACCAAATATCCTTGAATGAATTCACTTCTAAAAGCC GTGAACTCTCCTGGCATCAAGTTAGCAAAGCACCAGCAATTGGTTTTAGTCCTTCTGTGTTACCAAAACC TCAAAATACGAATAAAGAATGCTCCTGGGGAAGCCCCATAGGAAAACATCATGGTGCTGATGATTCCAGA TTCAGTATTTTAGCTCTATCATTCACAAGTTTGGATAAAATTAATCTAGAGAAAGAATTAGAAAATGAAA ATCATAACTACCATATAGGATTTGAAAGTAGCATTCCTCCAACAAATTCATCCTTCTCAAGTGACTTCAT GCCGAAAGAAGAGAATAAAAGGAGTGGACATGTGAACATTGTGGAACCATCTTTGATGCTTTTGAAAGGC TCTCTTCAACCCGGAATGTGGGAAAGTACATGGCAGAAGAATATAGAGTCAATAGGTTGTTCCATTCAGC TAGTGGAAGTACCTCAAAGCAGCAATACGAGTCTGGCCTCTTTTTGCAACAAAGTAAAAAAAATCAGAGA AAGATATCATGCAGCTGATGTTAATTTCAATTCTGGGAAGATCTGGAGCACTACTACAGCATTTCCGTAT CAGCTCTTTTCTAAGACCAAGTTTAATATACATATTTTTATTGATAACTCAACACAACCTCTTCATTTTA TGCCATGTGCTAATTATCTTGTCAAAGATCTAATTGCAGAAATTCTGCATTTTTGCACAAATGACCAGCT ACTCCCCAAAGATCATATTCTAAGTGTATGTGGCTCTGAAGAATTTTTACAAAACGACCACTGTTTGGGG AGCCACAAAATGTTTCAAAAAGATAAATCTGTTATTCAGCTCCACCTGCAGAAAAGTAGGGAAGCTCCAG GAAAGCTATCTCGAAAGCATGAAGAGGACCACAGTCAGTTTTATCTGAATCAACTTCTAGAATTTATGCA TATTTGGAAAGTATCCAGACAATGTCTCTTAACACTCATCAGAAAATATGACTTCCACCTGAAATACCTA TTGAAAACCCAGGAAAACGTGTATAATATTATTGAAGAAGTTAAAAAAATATGCAGTGTTCTAGGGTGTG TGGAAACCAAACAAATTACAGATGCAGTAAATGAACTAAGTCTAATTCTTCAGAGAAAAGGAGAGAATTT TTATCAAAGTTCAGAGACTTCAGCAAAAGGCTTGATAGAGAAGGTAACAACTGAACTATCCACATCCATC TACCAGCTAATCAATGTCTACTGTAACAGCTTTTATGCAGATTTTCAGCCTGTAAATGTACCTAGATGCA CTTCCTATCTAAATCCCGGGCTTCCTTCCCACCTCAGCTTCACAGTGTATGCAGCACACAACATTCCAGA AACCTGGGTGCACAGGATCAATTTTCCCCTTGAAATAAAGTCACTTCCAAGGGAATCCATGCTCACTGTA AAACTGTTTGGGATTGCCTGTGCAACCAACAATGCAAATTTACTGGCGTGGACTTGTCTTCCACTGTTTC CAAAAGAAAAATCCATTCTCGGGTCTATGCTGTTCAGCATGACATTACAGAGTGAGCCTCCCGTAGAAAT GATAACTCCAGGAGTGTGGGATGTAAGTCAGCCATCCCCGGTGACCCTGCAGATTGATTTTCCAGCTACT GGGTGGGAGTATATGAAACCTGATTCTGAAGAGAATAGAAGTAATCTTGAAGAGCCACTAAAGGAGTGTA TAAAACATATTGCCAGACTTTCACAGAAACAGACTCCCCTACTACTCTCTGAAGAAAAGAAAAGATATTT ATGGTTTTATCGCTTCTACTGCAATAATGAAAACTGCTCCCTTCCTTTAGTCCTGGGTAGTGCCCCTGGA TGGGATGAAAGGACTGTTTCAGAAATGCATACCATTTTGAGAAGATGGACATTTTCTCAACCTTTAGAGG CTCTTGGGCTTTTGACTTCCAGTTTTCCAGATCAAGAAATTCGTAAAGTGGCAGTTCAACAATTAGACAA CCTCTTGAATGATGAACTACTGGAATATCTCCCACAGCTAGTTCAGGCTGTCAAGTTTGAATGGAACCTT GAGAGTCCTTTAGTGCAACTTCTACTCCACCGCTCCTTGCAGAGCATCCAGGTTGCCCATCGTCTTTACT GGCTGCTAAAAAATGCAGAAAATGAAGCTTATTTTAAAAGCTGGTATCAGAAGCTACTAGCTGCTCTCCA ATTCTGTGCAGGTAAAGCCTTGAATGATGAGTTTTCCAAGGAGCAGAAACTTATCAAAATTCTGGGAGAT ATTGGGGAAAGAGTCAAGTCTGCCAGTGACCATCAAAGACAGGAGGTACTGAAGAAAGAAATTGGCAGAC TAGAAGAGTTCTTTCAAGATGTAAATACTTGTCATCTTCCTCTGAACCCTGCCCTATGTATAAAAGGGAT TGATCACGATGCATGTTCATATTTTACATCTAATGCTTTGCCATTGAAGATTACTTTCATCAATGCTAAT CCGATGGGCAAAAACATCAGCATTATTTTTAAGGCTGGAGATGATCTTCGTCAGGATATGCTTGTTCTGC AGCTTATTCAAGTGATGGACAATATTTGGCTGCAGGAAGGCTTGGATATGCAAATGATCATTTATAGATG TCTATCCACAGGAAAAGACCAAGGATTGGTGCAGATGGTACCTGATGCTGTGACCCTAGCAAAGATTCAT CGCCATTCTGGACTGATAGGACCATTGAAAGAAAATACAATTAAAAAGTGGTTCAGTCAGCACAACCACT TAAAGGCAGATTATGAAAAGGCCTTGAGGAACTTTTTCTACTCCTGTGCTGGCTGGTGTGTGGTAACATT CATCCTGGGAGTATGTGACCGTCACAATGATAATATCATGCTGACAAAGTCGGGCCACATGTTTCATATT GACTTTGGAAAATTCTTAGGTCATGCACAAACATTTGGAGGGATAAAAAGGGACCGAGCTCCTTTCATTT TTACTTCAGAGATGGAATACTTTATTACAGAGGGTGGGAAAAACCCACAGCATTTTCAAGATTTTGTGGA ACTTTGCTGTCGTGCTTATAATATTATCAGAAAGCACAGCCAACTGCTCTTGAACCTGCTGGAAATGATG CTGTATGCAGGACTGCCTGAGCTAAGTGGAATTCAAGACCTGAAATATGTGTATAATAATCTTCGTCCAC AAGACACAGACCTGGAAGCAACAAGTCATTTTACCAAGAAAATAAAGGAAAGTCTGGAGTGTTTCCCTGT TAAATTGAATAACTTGATCCACACACTTGCACAAATGTCAGCCATAAGCCCTGCCAAATCTACTTCACAG ACTTTTCCTCAGGAATCCTGTTTGCTGAGTACAACTAGGTCGATTGAAAGAGCAACAATTTTAGGGTTCA GCAAGAAATCCAGTAATCTGTATCTGATCCAGGTGACACACAGCAACAACGAAACAAGCCTGACAGAAAA ATCATTTGAGCAGTTTTCAAAACTTCACAGCCAACTTCAGAAGCAGTTTGCATCACTGACTCTCCCAGAG TTTCCTCATTGGTGGCACCTACCTTTTACAAATTCAGATCACAGAAGATTCAGAGATCTAAATCATTACA TGGAACAGATATTAAATGTATCACATGAAGTTACAAACAGTGATTGTGTACTTAGCTTTTTCCTCTCTGA GGCTGTGCAACAAACAGTTGAAGAATCATCACCTGTGTACCTAGGTGAGAAGTTTCCAGACAAGAAGCCT AAGGTGCAGTTAGTCATATCCTACGAGGATGTGAAGCTGACCATACTAGTGAAACACATGAAAAACATTC ATCTCCCAGATGGCTCTGCGCCCAGTGCACATGTTGAATTTTATCTTTTACCATATCCCAGTGAAGTTCG TAGGAGGAAAACAAAATCTGTTCCAAAATGTACGGACCCCACTTACAATGAAATTGTAGTATATGATGAA GTCACAGAGCTCCAAGGACATGTCTTAATGCTTATTGTGAAGAGTAAAACTGTATTTGTGGGAGCAATTA ACATCCGACTCTGTAGTGTCCCACTCGATAAAGAAAAATGGTATCCATTAGGAAACAGTATAATT AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGA TAAGGTTTAA Protein Sequence (showhide) >RC402758 representing NM_004570 Red=Cloning site Green=Tags(s) MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDENTFFVPTAPK WDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGADDSR FSILALSFTSLDKINLEKELENENHNYHIGFESSIPPTNSSFSSDFMPKEENKRSGHVNIVEPSLMLLKG SLQPGMWESTWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPY QLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLG SHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYL LKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSI YQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHRINFPLEIKSLPRESMLTV KLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFPAT GWEYMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPG WDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNL ESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGD IGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINAN PMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIH RHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHI DFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMM LYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQ TFPQESCLLSTTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPE FPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPDKKP KVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDE VTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLGNSII SGPTRTRRLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NP_004561
RefSeq Size	4335 bp
RefSeq ORF	4338 bp
Locus ID	5288
Domains	C2, PI3_PI4_kinase, PI3Ka, PX, PI3K_C2
Protein Families	Druggable Genome
Protein Pathways	Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system
MW	159 kDa
Gene Summary	The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.