RET (NM_020975) Human Mutant ORF Clone

CAT#: RC403336

  • TrueORF®

RET Mutant (v804L), Myc-DDK-tagged ORF clone of Homo sapiens ret proto-oncogene (RET), transcript variant 2 as transfection-ready DNA



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CNY 7,760.00


货期*
现货

规格
    • 10 ug

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Specifications

Product Data
Product Name RET (NM_020975) Human Mutant ORF Clone
Mutation Description v804L
Affected Codon# 804
Affected NT# 2410
Nucleotide Mutation RET Mutant (v804L), Myc-DDK-tagged ORF clone of Homo sapiens ret proto-oncogene (RET), transcript variant 2 as transfection-ready DNA
Effect Multiple endocrine neoplasia 2
Synonyms CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1
Vector pCMV6-Entry
Tag Myc-DDK
ACCN NM_020975
ORF Size 3342 bp
Restriction Sites SgfI-MluI      Cloning Scheme for this gene     
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NP_066124
RefSeq Size 3342 bp
RefSeq ORF 3345 bp
Locus ID 5979
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Endocytosis, Pathways in cancer, Thyroid cancer
MW 122.5 kDa
Gene Summary This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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