Human Adducin 2 (ADD2) activation kit by CRISPRa

CAT#: GA100081

ADD2 CRISPRa kit - CRISPR gene activation of human adducin 2



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
Anti-ADD2 Rabbit Polyclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


ADD2 (Myc-DDK-tagged)-Human adducin 2 (beta) (ADD2), transcript variant 4
    • 10 ug

CNY 4,784.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol ADD2
Locus ID 119
Kit Components

GA100081G1, Adducin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100081G2, Adducin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100081G3, Adducin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001185054, NM_001185055, NM_001617, NM_017482, NM_017483, NM_017484, NM_017485, NM_017486, NM_017487, NM_017488, N53078
Synonyms ADDB
Summary Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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