Human Aggrecan (ACAN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ACAN
Locus ID	176
Kit Components	GA100124G1, Aggrecan gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100124G2, Aggrecan gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100124G3, Aggrecan gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001135, NM_013227, NM_001369268
Synonyms	AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
Summary	This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]

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