Human S adenosylhomocysteine hydrolase (AHCY) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AHCY
Locus ID	191
Kit Components	GA100135G1, S adenosylhomocysteine hydrolase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100135G2, S adenosylhomocysteine hydrolase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100135G3, S adenosylhomocysteine hydrolase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000687, NM_001161766, NM_001322084, NM_001322085, NM_001322086, NM_001362750
Synonyms	adoHcyase; SAHH
Summary	S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

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