Human Complement C4B (C4B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	C4B
Locus ID	721
Kit Components	GA100501G1, Complement C4B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100501G2, Complement C4B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100501G3, Complement C4B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000592, NM_001002029
Synonyms	basic C4; C4B1; C4B2; C4B3; C4B5; C4B12; C4F; C4F, CO4, C4B1, C4B3, CPAMD3; CH; Chido form of C4; CO4; complement C4B1a; complement component 4B; complement component 4B (Chido blood group); CPAMD3; FLJ60561; MGC164979; OTTHUMP00000029269
Summary	This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, May 2020]

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