Human p57 Kip2 (CDKN1C) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CDKN1C
Locus ID	1028
Kit Components	GA100740G1, p57 Kip2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100740G2, p57 Kip2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100740G3, p57 Kip2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000076, NM_001122630, NM_001122631, NM_001362474, NM_001362475
Synonyms	BWCR; BWS; KIP2; p57; p57Kip2; WBS
Summary	This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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