Human Cannabinoid Receptor I (CNR1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CNR1
Locus ID	1268
Kit Components	GA100888G1, Cannabinoid Receptor I gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100888G2, Cannabinoid Receptor I gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100888G3, Cannabinoid Receptor I gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001160226, NM_001160258, NM_001160259, NM_001160260, NM_001840, NM_016083, NM_033181, NM_001365872, NM_001370545, NM_001365869, NM_001365870, NM_001365874, NM_001370546, NM_001370547
Synonyms	CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Summary	This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

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